Effects of novomanin on tissue regeneration

The reduction of microflora in purulent wounds in the treatment of patients with Novimanin P. P. Volosovets (19646) noted already in the first days of antibiotic use – after 2–3 days the number of colonies sown from pus was significantly less than before the start of treatment; after 5 days, microbes were not detected in crops in 51.6% of patients, after 10 days in 83.7% of patients; Not only gram-positive, but also some gram-negative bacteria (Escherichia coli) that were sensitive to the new umanin disappeared from the pus.

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In the treatment of patients with a new name, from whose pus wounds an associated flora was sown (Staphylococcus aureus, hemolytic streptococcus, Escherichia coli), the staphylococcus disappeared later than other species. But on Proteus vulgaris , and Ps . aeruginosa antibiotic effect was weaker; its combination with colimycin or polymyxin M led to favorable results in all cases. In the process of treatment with neomanin in pathogens sown from foci, changes in the size and shape of staphylococcal colonies were observed, the latter losing their characteristic arrangement in clusters and changing tinctorial properties. Morphological changes in the cells during the treatment with neuromanin occurred also in the pseudomonas aeruginosa and vulgar proteus; the latter, on the 10th – 15th day of the use of the new mania, lost creeping growth, while in Ps. aeruginosa weakened ability to pigmentation.

A study of the dynamics of the influence of neomanin on tissue regeneration showed that, in parallel with the decrease in the number of microbes, the growth of fresh granulations and epithelialization intensified. Cytological studies have shown that macrophages appeared in a large number, polyblasts, already on the 3rd-5th day after the start of the use of Novoimanin; phagocytosis increased; the number of regenerative cells gradually increased, the degenerating cells decreased. The enhancement of regenerative processes was observed in all cases and corresponded to the dynamics of the microflora, the clinical picture of the pathological process, which usually ended in complete recovery by the 10th day, sometimes even earlier.

A.F. Buryanov (1968) describes the use of novimanin in the complex treatment of newborn mastitis (in 46 children). The author notes that lately, the severe forms of mastitis, often occurring due to phlegmon of newborns, often caused by apathobiotic-resistant staphylococci. They are characterized by an acute onset and rapid spread of the process, and necrosis of the skin and subcutaneous tissue may occur. Novoymanin used by electrophoresis; after surgery, the cavity was drained with tampons moistened in a solution of noymenin (a 1% alcohol solution of a new name was diluted 1:10 with a 10% solution of glucose). In order to prevent complications of the upper respiratory tract, a new aerosol was used as an aerosol. After the use of complex treatment, the temperature normalized on the second or third day, the general condition improved. childAt the same time, the wound was cleaned, granulations activated, the size of the wound decreased. Bacteriological examination confirmed the clinical effect. The author considers the use of novomanin in the complex treatment of mastitis in newborns as an effective means of prevention and treatment. M.N. Kovalishin (1967) applied the new umanin in 86 patients in the orthopedic and traumatology department. The preparation was placed under plaster dressings to the wounds in the form of lotions for a long time. At the same time, good tissue regeneration was observed; skin irritation or other complications are noted. According to the author, novoimanin is a good auxiliary means of local action in the complex treatment of patients.